Given the important roles of actomyosin-associated proteins in promoting NK cytotoxicity at the immune synapse (Krzewski et al., 2006; Carisey et al., 2018; Matalon et al., 2018), we hypothesized that Eomes and/or T-bet nuclear localization may be associated with NK intracellular contractility beyond the immune synapse, potentially triggered by TGFβ, and this might influence NK cytotoxicity against cancer cells. Here, EOMES is linked to cancer.