TBX21 and cancer: Given the important roles of actomyosin-associated proteins in promoting NK cytotoxicity at the immune synapse (Krzewski et al., 2006; Carisey et al., 2018; Matalon et al., 2018), we hypothesized that Eomes and/or T-bet nuclear localization may be associated with NK intracellular contractility beyond the immune synapse, potentially triggered by TGFβ, and this might influence NK cytotoxicity against cancer cells.