This prompted us to further identify the extrinsic and/or intrinsic trigger(s) of intracellular contractility-mediated Eomes nuclear localization induced in ex vivo NK-NSCLC coculture, with a view to elucidating the mechanisms underlying such a promotion of NK cytotoxicity against the invasive NSCLC subtype. Here, EOMES is linked to non-small cell lung carcinoma.