To study the mechanistic roles of Eomes and T-bet in NK cells during cancer surveillance, we tested: 1) primary human NK (hNK) cells, which are CD3−CD56+Tbet+Eomes+ (Supplementary Figure S1A), and 2) NK-92 cell line, which is Tbet+Eomes+ (Supplementary Figure S1B), on their anti-cancer capacity against two non-small cell lung cancer cell (NSCLC) subtypes, H1299 (aggressive invasive subtype) and H1975 (less invasive subtype) cells. Here, TBX21 is linked to cancer.