MYOC and open-angle glaucoma: In a recent study, the CRISPR/Cas9 system was used to disrupt the mutant MYOC gene in human and mouse TM cells and Ad5-crMYOC was intravitreally injected into transgenic POAG mice expressing mutant myocilin (Tg-MYOCY437H) (Jain et al., 2017).