In particular, compared with carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA19-9) termed asstandard and widely-known biomarkers and the detection of PC, circulating miR-25 could also be a promising biomarker for the diagnosis of early-stage PC owing to its high specificity (Deng et al., 2016). The gene discussed is CEACAM5; the disease is pachyonychia congenita.