TGFB1 and pachyonychia congenita: The combination of gene silencing of TGF-β1 (ppp-TGF-β) and immune activation via the cytosolic helicase retinoic acidinducible gene I (RIG-I) could remodel the immunosuppressive environment by recruiting CD8+ T cells and exert promising antineoplastic effects in PANC-1, MIA PaCa-2, and BxPC-3 cell lines as well as an orthotopic mouse model of PC.