Furthermore, in the tumor tissues of PTC patients without lymph node metastasis, BRAFV600E mutation is not significantly related to the Snail IHC score (Figure 5C left); while in the tumor tissues of PTC patients with lymph node metastasis, Snail IHC score in the BRAFV600E mutation group was significantly higher than that in the BRAFWT group (p=0.0072) (Figure 5C right). This evidence concerns the gene SNAI1 and metastatic malignant neoplasm in the lymph nodes.