INS and hyperinsulinism: = Body weight gain in both mice models↑ Fasting glucose in db/db mice + arsenic↑ Hyperinsulinemia in db/m mice + arsenic↓ Insulin levels in db/db mice + arsenic= HOMA-IR in both mice models↑ Glucose intolerance in db/db mice + arsenic↓ Insulin resistance in db/db mice + arsenic (ITT)↑ FFA in adipose tissue