↑ HOMA-IR in ovariectomized females + 0.05 and 0.5 ppm arsenic↑ Fasting glucose↓ Fasting insulin in sham females + arsenic↑ Hyperinsulinemia in ovariectomized females + arsenic↑ Insulin resistance in ovariectomized females + arsenic (ITT)↑ Glucose intolerance in ovariectomized females + arsenic. The gene discussed is INS; the disease is Hyperinsulinemia.