Low-density lipoprotein-docosahexaenoic acid (LDL-DHA) induces ferroptosis in HCC by regulating lipid metabolism, and regulation of lactic acid mediated by hydroxycarboxylic acid receptor 1/monocarboxylate transporter 1 (HCAR1/MCT1) also affects ferroptosis (Ou et al., 2017; Zhao et al., 2020). Here, HCAR1 is linked to hepatocellular carcinoma.