The increase of MUC1 mucin in the gallbladder epithelium can promote the absorption of cholesterol in mice and inhibit the movement of the gallbladder, thereby promoting the formation of gallstones (Wang et al., 2006; Chuang et al., 2011) found MUC1 and MUC2 gene loci significantly associated with gallstones in Chinese males. This evidence concerns the gene MUC1 and gallstones.