RYR2 and cancer: The top 10 genes with the highest mutation frequency among pan-cancer patients are: TTN (31%), MUC16 (20%), TP53 (18%), CSMD3 (13%), LRP1B (13%), RYR2 (13%), SYNE1 (12%), USH2A (11%), FLG (12%), and PIK3CA (14%) (Figure 4A).