In colorectal cancer and melanoma, BACH1 heterodimerizes with MAF BZIP Transcription Factor G (MAFG), cooperating with chromodomain helicase DNA-binding protein 8 (CHD8) and DNA Methyltransferase 3 Beta (DNMT3B) to inhibit the transcription of many antioncogenes (Fang et al., 2014; Fang et al., 2016). Here, CHD8 is linked to colorectal cancer.