Missense mutations within the cDNA could cause either severe or moderate retinopathy, however when missense mutations were sub categorised by the functional region of the NDP protein affected, cysteine mutations were found to universally result in severe retinopathy whereas LRP 5/6 binding site mutations universally caused moderate disease (Table 4; Figures 2, 5, 6). The gene discussed is NDP; the disease is retinal disorder.