However, if their cases are classified into ‘severe’ and ‘moderate’ groups as according to our system, all of the LRP binding sites result in FEVR-like ‘moderate’ retinopathy, all but one of their listed FZD4 binding sites produce a norrie-like ‘severe’ phenotype and all of their listed cysteine mutations result in a norrie-like ‘severe’ phenotype. The gene discussed is FZD4; the disease is retinal disorder.