Subsequent multivariate logistic regression (gender, diabetes, TG, HDL-C, FBG, IL-4, IL-12p70, IL-17 and IFN-α were taken into account) revealed that IL-12p70 (OR = 0.572, 95%CI: 0.454–0.720, P < 0.001), IL-17 (OR = 0.930, 95%CI: 0.886–0.976, P = 0.003) and HDL-C (OR = 0.232, 95%CI: 0.091–0.593, P = 0.002) were independent predictors for severe CAD. The gene discussed is IL17A; the disease is diabetes mellitus.