In addition, the roles played by some cytokines such as interleukins-4 (IL-4) and interleukin-17 (IL-17) in CAD is controversial, elevated levels of IL-4 and IL-17 had been reported in patients with ACS (11, 12), however, it had also been suggested that they may exert atheroprotective effects (13, 14). This evidence concerns the gene IL17A and coronary artery disorder.