The purpose of this study was to investigate the relationship between serum cytokines (IL-1β, IL-2, IL-4, IL-5, IL-6, IL-8, IL-10, IL-12p70, IL-17, TNF-α, IFN-α, and IFN-γ) and the severity of CAD, and determine the predictors of severe CAD to identify patients with more severe coronary artery lesions from people suspected to have CAD but AMI had been ruled out. Here, IL2 is linked to coronary artery disorder.