Our study data showed that the levels of IL-4 and IL-17 levels decreased in the severe CAD group comparing to the non-CAD group and mild CAD group, this result preferred that IL-4 and IL-17 might have a protective effect on the development of atherosclerosis and it was also possible that they played different roles at different stages of atherosclerosis, but at least the low levels of circulating IL-4 and IL-17 in patients suspected to have CAD were suggestive of more severe coronary lesions. The gene discussed is IL17A; the disease is coronary artery disorder.