It is reported that the elevated concentration of interleukin-1beta (IL-1β), Interleukin-2 (IL-2), interleukin-6 (IL-6), interleukin-8 (IL-8), interleukin-12p70 (IL-12p70), tumor necrosis factor-alpha (TNF-α), and interferon-gamma (IFN-γ) were associated with the increased risks of acute coronary syndrome (ACS) (6–9). The gene discussed is TNF; the disease is acute coronary syndrome.