PTGIS and heart failure: The accumulation of ROS can induce the formation of advanced glycation end products (advanced glycation end products, AGEs), stimulate the expression of AGEs receptor, and inhibit the activity of NO synthase (nitric oxide synthase, NOS) and prostacyclin synthase (prostacyclin synthetase, PGIS), which will promote myocardial fibrosis, diastolic dysfunction and even heart failure in patients with diabetes (Quan et al., 2020).