In addition, cytochrome P450 has a close relationship with inflammation in T2DM thought to decrease P450 isoenzymes and rise in plasma levels of these enzymes, finally resulting in high expression of interleukin-6 (IL-6) and the tumor necrosis factor-alpha (TNF-α) (Darakjian et al., 2021). Here, CYP2B6 is linked to type 2 diabetes mellitus.