Unadjusted multivariate Cox regression analyses demonstrated that LVEF < 40%, LAVI > 39 ml/m2, NT-proBNP > 2,250 pmol/ml and irisin < 6.50 ng/ml were the strongest predictors for CV composite outcomes in HF patients with T2DM. This evidence concerns the gene NPPB and type 2 diabetes mellitus.