ACKR3 and familial pancreatic carcinoma: MiR-101 is related to clinical outcomes of worse prognosis in several types of tumors, such as cervical cancer (51) and pancreatic cancer (52), regulating genes such as: mTor (mammalian target of rapamycin), ROCK1, ACKR3 (atypical chemokine receptor 3), MCL1 (MCL1Apoptosis Regulator, BCL2 Family Member) and RAC1 (Rac Family Small GTPase 1), which participate in important pathways in the mechanism of carcinogenesis (53).