We used the cBioportal data bank to explore the correlations between RCN3 expression and promoter DNA methylation levels, the results revealed a significant negative correlation between RCN3 expression and DNA methylation in BLCA, BRCA, CESC, CHOL, LIHC, ESCA, HNSC, KIRC, LIHC, LUAD, LUSC, ESO, PAAD (pancreatic adenocarcinoma), PRAD (prostate adenocarcinoma), READ, SARC, SKCM, STAD, UCEC and UCS (Supplementary Figure 2). This evidence concerns the gene RCN3 and pancreatic adenocarcinoma.