Chemokines and chemokine receptors such as CCL2, CCL11, CXCR5, CXCR4, CXCR3, CCR10, CCR2, and CCR1 were also positively correlated with RCN3 expression in most cancer types. The interaction between tumors and tumor immune microenvironment is complicated. The gene discussed is CXCR4; the disease is cancer.