As shown in Figure 1A, up-expression of RCN3 was observed in most cancer types, such as LUSC (lung squamous cell carcinoma), LUAD (lung adenocarcinoma), LIHC (liver hepatocellular carcinoma), KIRC (kidney renal clear cell carcinoma), HNSC (head and neck squamous cell carcinoma), ESCA (esophageal carcinoma), COAD (colon adenocarcinoma), CHOL (cholangiocarcinoma), BRAC (breast invasive carcinoma), and GBM (glioblastoma multiforme). The gene discussed is RCN3; the disease is cholangiocarcinoma.