Likewise, the Asian Cancer Research Group (ACRG) has also defined four GC molecular subtypes based on the epithelial-to-mesenchymal transition (EMT), microsatellite instability (MSI), and TP53 activity: MSI, microsatellite stable (MSS)/EMT, MSS/TP53+ and MSS/TP53− (24, 25). The gene discussed is TP53; the disease is cancer.