JAK2 and familial pancreatic carcinoma: Oncogenic JAK2/STAT3 is activated by exposure to IL-6 in pancreatic cancer cells to directly up-regulates the expression of regenerative gene protein 3A (REG3A), activation of REG3A will instead enhance the JAK2/STAT3 pathway, leading to the amplification of carcinogenic effects of IL-6/JAK2/STAT3 (29).