TNF and infection: Consistent with the results in the cell infection model, mice infected with WT Mm strain expressed more FBXW7 expression both at 14th dpi and 21st dpi (P < 0.01), lower TNF-α expression at 14th dpi (P < 0.01) and lower TGF-β expression at the 21st dpi (P < 0.01) compared to the △PDIM group (Figures 5D, E), respectively.