PTBP1 was also reported to regulate the phosphatase and tensin homolog-phosphatidylinositol-4,5-bisphosphate 3-kinase/protein kinase B (PTEN-PI3K/Akt) pathway and autophagy, thus inducing the proliferation, invasion, and metastasis of breast cancer cells [39]. This evidence concerns the gene AKT1 and breast cancer.