The logistic regression model combining the five mRNA biomarkers (CCNI, EGFR, FGF19, FRS2, and GREB1) can distinguish patients with lung cancer from normal controls (area under the receiver operating characteristic curve [AUC-ROC] = 0.925; sensitivity = 93.75%; specificity = 82.81%). The gene discussed is EGFR; the disease is lung carcinoma.