This might be related to the fact that TNFα has a bi-functional role in the growth of hematopoietic stem and progenitor cells and its inhibition is associated with the onset of lymphoproliferative disorders and pathological abnormalities (Autrel-Moignet and Lamy, 2014[2]; Bessissow et al., 2012[6]; Picchianti Diamanti et al., 201[30]; Tian et al., 2014[42]). The gene discussed is TNF; the disease is lymphoproliferative syndrome.