For example, PI4KB is co-amplified with PIPK1A, AKT3 and PIK3C2B (all localized to chromosome 1q) in over 60 % of human breast tumor samples where this quartet of phosphoinositide metabolizing genes was postulated to enhance phosphoinositide signaling resulting in increased cell proliferation and motility and a more aggressive phenotype (Waugh, 2014[86]). This evidence concerns the gene PI4KB and breast neoplasm.