The loss-of-function mutations in the DNAJC6 gene, which encodes HSP40 auxilin, has been linked with early-onset forms of PD (Olgiati et al., 2016) and midbrain organoids with this mutation showed DA neuron degeneration, α-syn aggregation and mitochondrial and lysosomal dysfunction. The gene discussed is DNAJC6; the disease is Parkinson disease.