Besides intervening as muscarinic receptor agonists, anti-oxidants, anti-amyloid inhibitors, AChE and BuChE inhibitors, α-synuclein agglomeration inhibitors, dopaminergic and nicotine agonists, alkaloids help to alleviate the pathophysiology of AD (Rahman and Muralidharan, 2010). The gene discussed is ACHE; the disease is Alzheimer disease.