To explore a potential clinical role of TIGIT+Helios+ CD8+ T cells, we analyzed their presence and activation status in the peripheral blood of older adults suffering from an acute influenza-A infection (63-83 years of age, n=15; H3N2 n=12, H1N1 n=3) obtained at the acute phase of influenza and during follow-up at two and eight weeks. Here, TIGIT is linked to influenza.