NRP2aHigh TAMs had increased levels of MMP9 (30.5-fold), Tie-2 (20-fold), VEGFA (14.5-fold), and HIF-1α (10.6-fold) transcripts compared to NRP2aLow TAMs, suggesting that NRP2a may either identify a unique subset of TAMs capable of responding to tumor hypoxia, or alternatively, that factors within avascularized regions may selectively induce NRP2a expression. This evidence concerns the gene VEGFA and neoplasm.