Figure 1B illustrates a representative staining of CD19 and CD138 on lymphocytes from the spleen of T. cruzi-infected WT-BCR and MD4 mice. Infection of MD4 mice showed that plasmablast induction depends on BCR signaling, since plasmablasts were almost absent from infected MD4 mice compared to WT mice around the peak of the plasmablast responses at 14 Dpi (Figure 1B, left and right graphs). This evidence concerns the gene BCR and infection.