CD8A and nonpapillary renal cell carcinoma: CIBERSORT analysis was also used to assess the proportion of 22 lymphocytes in the TME of ccRCC (Figure 7B), and the result showed that the TME of the high-risk group was composed of more T-cell CD4+ memory activated/resting, T-cell CD4+ naïve, T-cell CD8+, and less macrophage M2.