INS and Hyperinsulinemia: We also found that HIs in SC and DC grafts retrieved from the IP site had higher proportions of beta cells (insulin+ cells) and a lower proportion of alpha cells (glucagon+ cells) in each islet than HIs in NC and CC grafts (Figure 5E), suggesting that islet composition in alginate microencapsulated grafts was altered after transplantation, which could help explain the observed hyperinsulinemia.