AFP and neoplasm: The clinical characteristics were different between different subtypes, for example, the proportion of patients who were alive, age ≥65 years, male, TNM stage I‐II in the C1 subtype was higher than the other two subgroups, while the proportion of patients who died, age <65 years, vascular invasion, main tumor size >5 cm, AFP >300 ng/ml, poorly differentiated histology grade (G3‐4), and advanced stage (TNM stage III–IV, BCLC phase B‐C, and CLIP scoring ≥2) in the C2 subtype was greater than the other two subtypes (Figure 3E).