More than 10 studies reported the same outcomes, including ORR, DCR, KPS, thrombocytopenia, liver/renaldysfunction, neurotoxicity, nausea/vomiting, diarrhea, leukopenia, CD3+ T cells, CD4+ T cells, CD8+ T cells, CD4+/CD8+ T cells ratio, and CEA. This evidence concerns the gene CD8A and Decreased total leukocyte count.