However, LEMD2 expression was significantly negatively correlated with macrophages (r = − 0.161, p < 0.001), neutrophil cells (r = − 0.185, p = 0.015), mast cells (r = − 0.154, p < 0.001), dendritic cells (r = − 0.109, p < 0.001), B cells (r = − 0.114, p = 0.011), Th1 cells (r = − 0.204, p < 0.001), and Th17 cells (r = − 0.097, p = 0.03) in PRAD (Fig. 5C). Here, LEMD2 is linked to prostate adenocarcinoma.