We found that the expression of FAM83A, FAM83D, FAM83E, FAM83F, FAM83G, and FAM83H were significantly higher in breast cancer tissues compared to normal tissues (P = 1.63E − 12, Fig. 1A; P < 1E − 12, Fig. 1D; P = 1.62E − 12, Fig. 1E; P = 4.49E − 10, Fig. 1F; P = 1.67E − 12, Fig. 1G; P < 1E − 12, Fig. 1H). The gene discussed is SACK1E; the disease is breast cancer.