Since the expression level of transcriptional factors should be positively or negatively correlated with circPDE5A in PCa, FOXO4, CEBPB, and STAT5a were selected as the candidate transcriptional factors that might regulate circPDE5A expression according to the correlation analysis results in 30 paired PCa tissues (Supplementary Fig. 7C). Here, FOXO4 is linked to posterior cortical atrophy.