Another report revealed that in patients with hepatocellular carcinoma (HCC) that ended by the cirrhotic liver, the BARD1 gene showed significant hypomethylation (13.3%) in comparison to normal controls BARD1 hypomethylation was suggested as a predictive biomarker for predisposing to aggressive disease in HBV-negative patients [48]. The gene discussed is BARD1; the disease is hepatocellular carcinoma.