Furthermore, the BRCA1/BARD1 heterodimer interaction was disrupted by BARD1 or BRACA1 mutations associated with the presence of breast cancer, such as mutations of the RING finger domain [24, 25], missense mutations [26–28], and alterations of ANK sequences that are involved in the regulation of transcription [29]. The gene discussed is BRCA1; the disease is breast carcinoma.