Moreover, a genome-wide association study (GWAS) of breast cancer declared identification of 65 novel loci associated remarkably with a high risk of breast cancer at P < 5 × 10− 8 such as FES, MAP 3 K11, CLK2, GRK7, USP25, DFFA, PKP1, and ZKSCAN3 [51]. Here, USP25 is linked to breast cancer.