Accordingly, molecular studies conducted in the last few years have characterized PLSCR1 as a key factor not only in cellular pathways at the plasma membrane level, but also within the nucleus, including the rRNA transcription control [17], the oxidative stress response [18], the regulation of cancer cell survival and proliferation [19–21], the autophagy process [22–24], and antiviral responses [25–32]. This evidence concerns the gene PLSCR1 and cancer.