We previously demonstrated the clinicopathological significance of several cancer-associated molecules including fibroblast growth factor receptor 2 (FGFR2), transforming growth factor-beta 1 (TGFβ1), C-X-C chemokine receptor 2 (CXCR2), CXCR4, and phospho-Smad2 expressed at primary gastric tumors [10–14]. This evidence concerns the gene SMAD2 and cancer.