We thus conducted the present study to (1) examine the correlation between the molecular intra-tumoral heterogeneity and HER2 / ERBB2 expression and lymph node metastasis in gastric tumors in order to clarify the mechanism(s) responsible for lymph node metastasis, and (2) investigate potential therapeutic targets against lymph node metastasis. Here, ERBB2 is linked to gastric neoplasm.