EGFR and non-small cell lung carcinoma: In EGFR T790M-positive NSCLC, the PFS and OS of the patients with PE were significantly shorter in comparison to the patients without PE (median PFS 16.8 vs. 8.3 months, p = 0.003; median OS 44.9 vs. 14.2 months, p = 0.007) (Figs. 2B, 3B).