PPARGC1A and acute kidney injury: Moreover, in addition to the inflammation, Haohao Shi et al.33have demonstrated that cisplatin treatment activated caspase mitochondrial cascade apoptosis in the kidney, while suppressing the imbalance of oxidative stress via activation of SIRT1/PGC‐1α and inhibition of MAPK pathway could reverse mitochondrial cascade apoptosis and alleviated kidney injury in AKI.