Subsequently, a GWAS and HLA fine mapping study of 1126 Han Chinese PBC patients and 1770 controls showed that DRB1 (with DRB1*08:03) and/or DQB1 (with DQB1*03:01) picked up most of the signals, with DPB1 (DPB1*17:01) being an independent locus [40]. The gene discussed is HLA-DRB1; the disease is primary biliary cholangitis.