Screening 534 acute myeloid leukaemia (AML) genomes38,39 for variants in ZNF318 and HIST2H3D identified only one possible oncogenic mutation in ZNF318 (Supplementary Table 9), showing that although these variants are under selection in HSC/MPPs, they do not necessarily contribute to malignancy. Here, ZNF318 is linked to acute myeloid leukemia.