In the CFTR-France Database that currently includes 5267 individuals among whom 3135 patients with CF from ten French laboratories (https://cftr.iurc.montp.inserm.fr/cgi-bin/home.cgi), few splicing mutations are among the 40 more frequent CFTR mutations in France (>0.3%): c.2657+5G>A (2789+5G>A), c.1585−1G>A (1717−1G>A), c.579+1G>T (711+1G>T), c.2988+1G>A (3120+1G>A), c.489+1G>T (621+1G>T), and c.3873+1G>A (4005+1G>A). This evidence concerns the gene CFTR and cystic fibrosis.