CFTR and cystic fibrosis: More recently, it was reported that the 2′-O-methyl/PS-based AON improves by 3-fold the CFTR chloride channel currents (versus 2-fold by VX770/VX809) in CF patient-derived nasal and bronchial epithelial cells (p.Phe508del/c.3718-2477T) [88, 89].