As shown in Fig. 7, MYC, EGFR, LNX1, YBX1, HSP90AA1, ESR1, FN1, TK1, ANLN and SMAD9 achieved an AUC value of > 0.9, demonstrating that these genes have high sensitivity and specificity for T1DM diagnosis. This evidence concerns the gene ESR1 and type 1 diabetes mellitus.