CXCL1 and infection: During lung infection, NLRP6 on the one hand exacerbates inflammation induced by the gram-positive S. aureus71,72, and on the other, it reduces bacterial load and increases survival after infection with the gram-negative Klebsiella pneumonia controlling NETosis through of C-X-C motif chemokine ligand 1 (CXCL1)73 (Fig. 2c).