In contrast to the protective role that NLRP6 plays in NASH, alcoholic hepatitis, and allogeneic transplantation, in this case, it contributes to the formation of hepatic granuloma and aggravates the injury produced by this specific parasite (Fig. 2f), a fact that has been confirmed by the enhanced production of the anti-inflammatory cytokine IL-10 in spleen cells from Nlrp6−/− infected mice followed by reduced production of CCL2, CXCL1, and CCL in the liver87,88. The gene discussed is NLRP6; the disease is metabolic dysfunction-associated steatohepatitis.