Different metabolites such as taurine, carbohydrates, and long-chain fatty acids are known as activators of NLRP6, which in turn reduces DSS colitis, whereas histamine and spermine are reported to be the suppressor of the NLRP6 inflammasome, which in turn exacerbates the DSS-induced colitis46. The gene discussed is NLRP6; the disease is colitis.