NLRP6 and cancer: In line with the importance of NLRP6 in gastric cancer, another recent study shows that a long non-coding RNA named OIP-AS1 interacts with the zeste homolog 2 (EZH2), which is part of an essential polycomb repressive complex 2 whose deregulation is associated with different diseases, especially cancer, and contributes to gastric cancer cell growth and migration due to epigenetic silencing of NLRP6 transcription67,68 (Fig. 2e).