The overexpression of some hub genes such as fn1, platelet-derived growth factor receptor beta (pdgfrb), col1a1, versican (vcan), plasminogen activator inhibitor-1 (serpine1), immunoglobulin superfamily containing leucine rich repeat (islr), cluster of differentiation 36 (cd36), fibrinogen gamma chain (fgg), ghrelin and obestatin prepropeptide (ghrl), and coagulation factor II thrombin receptor (f2r) showed a negative impact on the survival of patients suffering from gastric cancer. Here, ISLR is linked to gastric cancer.