However, in a previous study of BCR-ABL1 ALL [7], we demonstrated that MRD analysis using conventional MRD markers based on immunoglobulin and T-cell receptor (Ig/TCR) rearrangements fails to detect or underestimates MRD compared to qPCR genomic tests detecting the BCR-ABL1 gene fusion itself in some CML-like patients. The gene discussed is BCR; the disease is acute lymphoblastic leukemia.