KDM5B and melanoma: As confirmed by flow cytometric analysis and by immunocytology, the top hit compound 2-phenoxyethyl-4-(2-fluorophenyl)-2,7,7-trimethyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate (PubChem name BAS00915510, here abbreviated Cpd1) reproducibly increased KDM5B protein levels irrespective of the genotype of the melanoma cell lines tested (Fig. 1e, f and Supplementary Table 1).