Importantly, KDM5B-associated differentiation reprograming was similarly induced by Cpd1 in patient-derived CSM152 melanoma cells (Fig. 4a, b and Supplementary Fig. 8a, e) and was also confirmed in silico for endogenous gene expression in single melanoma cells isolated from human tumor tissue (n = 1253 melanoma cells from 19 tumors40). Here, KDM5B is linked to melanoma.