Among these SMGs, MACF1 (5.17%, 18/348) and AXIN1 (0.86%, 3/348, all of the three patients were with iCCA), which is commonly considered as one of the potential drivers in hepatocellular carcinoma (HCC), are two interactive components of the β-catenin/Wnt signaling pathway (Fig. 2). Here, AXIN1 is linked to hepatocellular carcinoma.