TP53 and cancer: Next, we performed pathway enrichment analysis on all potential driver genes identified in this study, which included SMGs (mut-drivers) and cancer genes in the frequently altered focal CNA regions (CNA-drivers) described above, and found that the potential driver genes of CCA were significantly enriched in the RTK-RAS, Wnt, PI3K, Cell Cycle, TP53, TGF-beta, and HIPPO pathways (Fig. 3C).