Consistent with our previous reports10,30, the transplantation of p190-BCR-ABL-expressnig WT or Vav3−/− leukemic LDBM cells leads in both cases to leukemogenesis as demonstrated by the detection of lymphadenopathies, hepatosplenomegaly, and extraosseus tumors in head and neck (data not shown). This evidence concerns the gene ABL1 and Lymphadenopathy.