TGFB1I1 and cancer: We show here the exemplar that nuclear FAK, as part of a nuclear adhesion protein network, forms a compensatory association with Hic-5 to co-regulate the expression of a subset of cytoskeletal and adhesion proteins that can localise to the nucleus; this adds to our understanding of the mechanisms by which nuclear FAK is known to affect transcription and cancer cell communication with the extracellular environment25–28.