However, upon annotating decreased ATAC-peaks to their nearest gene and performing a GO analysis on those genes, we discovered that in contrast to differentiation and development genes, the genes with decreased ATAC-peak intensity were linked to several cancer hallmarks, including signaling, migration, and angiogenesis (Fig. 5f, g) in line with the role of AP-1 acting as a pro-oncogenic factor [27]. This evidence concerns the gene JUN and cancer.